400-407 Ciancaglini:Shoja
نویسندگان
چکیده
The toxicity of preservatives on conjunctival epithelium has been widely described in glaucomatous patients topically treated, suggesting both an indirect effect on the lacrimal film and a direct toxic action on epithelial cells (1). Previous studies indicate that long-term administration of preservative-containing eyedrops can lead to chronic conjunctival inflammation, ocular surface impairment, and to an increased risk for glaucoma surgery failure, due to the overexpression of several inflammationor apoptosisrelated molecules (2-4). Among all preservatives, benzalkonium chloride (BAC) is the most commonly used in the European Journal of Ophthalmology / Vol. 18 no. 3, 2008 / pp. 400-407
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